| Biological clockObviously you need
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| | read too many science fiction. When I was
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| biological clock to time and alarm the
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| | in medschool a saw some mentions of
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| point when you need to die and when you
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| | unusual phenomenon in magnetic radiation.
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| need to age. Aging is the same death as
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| | To make story short, eventually I found a
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| in those one-day butterflies, but a
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| | book - 400 pages of fine script. I found
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| little bit prolonged one. Not immediate
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| | the book in Central Medical Library in
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| kill but gradual shut down of protection
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| | Moscow. Even our relatively large library
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| mechanisms - immunological, genetical
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| | in Russian State Med U did not have this
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| repair, and just other necessary
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| | book. In addition I read the dissertation
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| functions of proliferation. As soon as
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| | thesis, that were related to that book.
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| those functions turned off - an organism
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| | Several Russian scientists developed
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| starts to deteriorate and wear
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| | relatively complicated theory, done many
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| off.Interesting that our organism is not
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| | hundreds of experiments. Theory is a
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| a static thing. We probably replace all
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| | little bit complex, involves discussion
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| molecules in our body within relatively
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| | of stress and adaptation syndrome.
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| short period of time. Obviously water is
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| | Obviously hypothalamic area also
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| replaced completely every couple months.
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| | discussed. I am not big fan of that
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| Water is 60% of our body. Other molecules
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| | theory. But result the authors described
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| are replaced as well. Thus, human being
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| | were striking: they were able to restore
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| is just some unstable chemical
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| | menopause in rats, prolong rats life span
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| organisation around genetical
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| | almost twice and more important repeat it
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| information. Molecules swirl and
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| | again and again. By the description from
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| disappear like crazy. DNA in cells maybe
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| | the book "rejuvenated rats" looked the
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| is not changed so fast, but the cells
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| | same as young, but were just bigger in
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| themselves change quickly in most of
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| | size. Well, you saw a lab rat, you know
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| cases. There is no need to age just
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| | that older rats have rare hair, bleak
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| because of wearing.Biological clocks are
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| | eyes, are in menopause etc. Young rat, in
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| necessary and there is no doubt they
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| | opposite, would have bright red eyes,
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| exist.The theories of aging that consider
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| | very sleek hair, menstruations, etc. This
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| death as a sequence of events caused by
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| | is no surprise - all growth of hair,
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| external causes - like oxidations and
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| | production of oil by skin, production of
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| accumulation of genetical errors should
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| | moisture in lacrimal glands and so on are
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| anyway include the idea of Internal
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| | regulated by the hormones. The same is
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| Biological Clock as well. Simple example
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| | true for rats as well as for
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| is menopause in women. Somewhere at 40-55
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| | humans.Authors described the methods that
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| all women undergo menopause. Unavoidable.
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| | they found mostly empirically. Moreover
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| Though there were reports of childbirth
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| | they tested some methods on humans and
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| at 60 yo but considering one chance in
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| | described treatment of variety of
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| billions, it is just a joke. Males have
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| | diseases - asthma, gastritis, peptic
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| their equivalents too. All people after
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| | ulcers, low grade skin cancers
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| certain age change their immunological,
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| | (non-melanoma) just to name few. As I
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| hormonal, metabolic levels and so on.
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| | understand they did not describe
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| Majority of organs decrease their
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| | rejuvenation in humans. Though later
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| function . Thymus involute. Fat cells
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| | there were some mentions in literature.
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| overgrow others, muscle cells degenerate
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| | Authors describe zones of activation,
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| etc. The same happens to all other
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| | training and stress. In general the
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| multicellular animals and plants.Now the
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| | methods are difficult to apply - they
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| real question: Is it possible to break
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| | require permanent control of organism
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| the biological clock or at least slow
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| | condition for many months, maybe years.
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| down and rejuvenate?Possible methods of
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| | Control of hormonal level and control of
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| rejuvenation.1. Telomeres lengthening and
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| | blood work. In addition parameter would
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| other genes regulation.Several genes that
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| | vary from individual to individual. In
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| might play role in aging described
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| | modern medicine it is much faster and
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| recently. Telomerase encoding genes are
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| | more reliable to cut out skin cancer with
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| the most discussed. In theory, if we
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| | knife or give powerful proton pump
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| lengthen the telomeres (these are the
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| | inhibitors for a gastric ulcer.I realized
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| ends of chromosomes that are shortened
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| | that I used some of the methods
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| with each division by very interesting
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| | described, even before I read that book.
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| mechanism), we could overcome cell
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| | Since then I added some more methods for
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| tendency to lose ability for
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| | my own use. Mostly I use the methods that
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| proliferation. Hence, we have "immortal
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| | I feel safe and efficient. For example
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| cells". Hence, immortality or at least
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| | transplanting of hypothalamus would be
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| longevity is reached - cells divide
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| | out of question. It is a wacking unsafe
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| indefinitely and repair organism.
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| | procedure. Recently there were reports
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| Basically, to restore telomeres length we
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| | that DHEA, melatonin or other hormones
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| need to activate production of or to
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| | could make miracles: older people feel as
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| introduce into the cell an enzyme named
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| | young. I would wait confirmation of the
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| telomerase. To reach each cell in the
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| | effects. Some authors suggest
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| body we would use viral vectors or
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| | rejuvenation may be reached by
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| smallRNA. Working with virus production
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| | individually designed cocktails of
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| and then cell transduction I would say it
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| | hormones. I would think that any hormone
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| is difficult, very difficult. There are
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| | given makes more mess than regulation.
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| too many obstacles to use them
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| | Practically every hormone described have
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| efficiently. SmallRNAs would be more
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| | loops and pathways that prevent
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| promising. In any case, when you go from
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| | overproduction. If you just replace the
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| theory to practice problems rise
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| | hormones by giving the substitute, you
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| exponentially. Biggest question: will it
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| | wack the production of your own hormones
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| work? Immortal cell (cell which is able
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| | those that injected as well as many
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| to divide indefinitely) does not mean
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| | others. All hormones are complexly
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| immortal body. One of the outcomes would
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| | interrelated. Individual cocktails would
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| be uncontrollable cell growth and, hence,
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| | be better, but the doses described in
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| cancer. Actually scenists discuss
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| | literature are wacking. Again I might be
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| telomeres mostly in connection with
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| | wrong. Maybe everything is so simple -
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| cancer. They are very cautious saying
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| | just get cocktail and you will jump as a
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| about the rejuvenation. Mass media
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| | newborn bunny.Considering different
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| extrapolates the findings to possibility
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| | information from different sources, I
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| of longevity and further rejuvenation.My
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| | would propose following theory:To
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| guess would be that telomeres are some of
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| | rejuvenate yourself you need to recreate
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| the "final cogwheels" in the Internal
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| | the hormonal and metabolic level of young
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| biological clock. It is useful to divide
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| | organism.This is actually very difficult
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| the clock on intracellular and whole body
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| | to reach: your organism have all the
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| levels just for understanding. But in
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| | means to produce all the necessary
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| reality the levels are not separable,
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| | hormones. Levels of hormones in elderly
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| they continue one into another. It is
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| | are not so far from the levels in youth
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| easy to understand that intracellular
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| | actually. The difference is several
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| production of any protein, any enzyme
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| | percentages, not several folds. But
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| depends on transmembrane regulation.
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| | biological clock switch to
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| Hormones activate receptors that activate
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| | underproduction. The idea is to cheat the
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| DNA transcription and protein production.
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| | biological clock and to restore the youth
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| Other genes that play role in cellular
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| | levels. The most difficult part is to get
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| aging are described recently as well. I
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| | into the window of optimal production.
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| do not know how to use this method at
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| | You can not go too low - just wouldn't
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| present time2. Hormone replacement.When I
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| | have any effect on rejuvenation. You can
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| studied in med school, several time I met
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| | not go above the optimal level - it will
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| mentions about hormonal side effects that
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| | cause stress and even more deterioration.
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| cause a person to look much younger. Well
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| | So approach is very individual. There is
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| known for example are: If a woman in
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| | no quick effect - you can not rejuvenate
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| menopause suddenly resumes menstrual
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| | from looking 50 to looking 30 overnight.
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| cycles and looks younger than her age, we
| |
| | You really need a lot of commitment and
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| might suspect an ovarian Tumour producing
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| | time. The methods which you choose are
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| excess of estrogen. If a person has
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| | not of so great importance. Practically
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| thyrotoxicosis - excess of hormone
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| | any action toward your body would cause
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| thyroxine - he/she loses weight and looks
| |
| | changes in your metabolic and hormonal
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| much younger Persons with manic phases of
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| | status. Physical exercise, herbs, yoga,
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| bipolar disorder look younger, more
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| | hormones (low doses) etc - we could list
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| energetic. Certain hormones -
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| | thousands.Personally I used available
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| corticosteroids for example - might be
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| | antioxidants, slight caloric
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| increased or decreased in elderly.
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| | restrictions, herbs (some of substances
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| Couples that look younger were shown to
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| | in herbs like ginseng, Echinacea, etc
|
| have increased level of sexual
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| | mimics hormones in their chemical
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| relationships. Again, that supposedly
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| | structure), self-hypnosis,
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| should significantly change the hormonal
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| | neurolinguistic programming (NLP),
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| levels.If we give a person some of those
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| | auto-training, different exercises,
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| synthetic hormones - estrogen, thyroxine
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| | lactic bacteria, etc. Important is the
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| - we can sometime reproduce the younger
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| | ability to adjust the level of treatment
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| looks.It is not the same as plastic
| |
| | - reduce the dose of herbs or increase
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| surgery or skin creams and massages. It
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| | dose of exercise etc.Methods of control
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| invigorates whole body. Skin as well.
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| | are of much great importance. The
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| There is heavy price - recent debates are
| |
| | described methods include measurement of
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| waxing and waning - if estrogen
| |
| | hormonal level and of certain fractions
|
| replacement increases or decreases risks
| |
| | of cells in the blood work(that is also
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| of cancers (uterine, breast, ovarian
| |
| | regulated by hormonal and metabolic
|
| etc.) Thyroxine excess takes heavy tall
| |
| | reactions)If I would have a clinic of
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| on cardiovascular system. Psychiatric
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| | rejuvenation therapy I would probably use
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| disorders (mania for example) was linked
| |
| | many of those methods - they are
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| to ceratin changes in neurotransmitter
| |
| | objective and reproducible. But they
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| levels. Certain psycho tropic drugs
| |
| | require blood work.For individual use
|
| change the ratios. Supposedly they can be
| |
| | there some subjective methods exist. They
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| employed for rejuvenation. Unfortunately,
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| | are described in literature as: If you
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| you would rather receive a psychosis than
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| | are in the condition of rejuvenation you
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| younger look.On internet you can find
| |
| | feel great energy, hunger, restlessness.
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| massive information about hormones that
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| | Your sleep would be normalised, you are
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| rejuvenate you. I saw some websites that
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| | fighting regular infections much more
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| list practically any major
| |
| | efficiently - inflammatory reaction might
|
| hormone:estrogenandrogenscorticosteroidsg
| |
| | be exaggerated, but they last shorter
|
| rowth hormonethyroxineDHEAmelatoninand
| |
| | time. Your eyes would glisten as in
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| some others as a drug that leads to
| |
| | youth. You will feel constant euphoria
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| rejuvenation.The websites often have
| |
| | and need in doing something. There are
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| references to scientific literature. Most
| |
| | some other subjective criteria.
|
| of the websites just sell you those
| |
| | Personally, I would add: you will notice
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| hormones or offer courses of hormone
| |
| | that your nails and hair grow like crazy
|
| therapy.My personal opinion would be that
| |
| | in those conditions.The biggest problem
|
| blind replacement can cause more harm
| |
| | is how to hold in this condition of
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| than lead to any desired
| |
| | rejuvenation for a prolonged period of
|
| rejuvenation.Useful information that I
| |
| | time. You really can not go overboard -
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| would extract from the item is that A)
| |
| | super activation would just wack all your
|
| Practically every hormone in the body is
| |
| | system. You can not go under activation -
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| involved. B) Certain means of
| |
| | just no any useful effect. You need to
|
| rejuvenation are actually documented.
| |
| | get it is just right. Solution is tight,
|
| That gives hope.I do not use hormones
| |
| | continuos control. Boy, it's really tough
|
| personally. If I would employ them, I
| |
| | in the modern stressful environment
|
| would use them in very small quantities
| |
| | (would not describe all the junk that I
|
| to mimic physiology and in special
| |
| | had in recent years), but it is possible.
|
| controlled conditions that I will
| |
| | Dedication is your solution. Some
|
| describe below. The doses that are used
| |
| | formulas to calculate doses of stimuli
|
| in regular therapy are actually way to
| |
| | are described in the literature, but I
|
| high compare to the natural levels of a
| |
| | feel it is easier to go with individual
|
| healthy organism.3. Antioxidant
| |
| | subjective feelings. Below there is an
|
| therapy.As we discussed, in the best case
| |
| | animation that contains some simple
|
| antioxidants are the method for
| |
| | elements of NLP and might help to tune a
|
| longevity, not rejuvenation. I use
| |
| | brain a little.Now, what did I get by
|
| mega-doses of antioxidants available over
| |
| | using those methods? Well not much, but I
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| the counter. I use only those that I
| |
| | hope for more. At present time I am 35 yo
|
| consider safe. I have a lot of doubts
| |
| | I do not really have good control group
|
| they give measurable effect. Anyway I use
| |
| | in my personal experiment. Sometime
|
| them. Would not throw away.4. Caloric
| |
| | people asked me if I am younger than my
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| restriction.I use it as well. 60% of
| |
| | brother (He is younger than me for
|
| regular meal - is way to much - you would
| |
| | several years). Maybe it is some sort of
|
| barely move your feet. I regulate it. My
| |
| | control group. When I come into a bar
|
| opinion: if you increase your activity,
| |
| | (can not say often, maybe once in a year
|
| you can eat more. Just balance your food
| |
| | with friends) waiter often asks my ID. It
|
| and motions. Though I might be wrong.5.
| |
| | is funny also because I do not use
|
| Hypothalamic regulation.This is scary
| |
| | alcohol. So, to drink a Coke I need to
|
| level. Hypothalamus is the area of your
| |
| | show ID, being 35 yo. Sometime people ask
|
| brain that sits on the base of your
| |
| | me are you 18 or 19 When I played water
|
| skull. Why do we discuss hormones above?
| |
| | polo at Yale, undergrads told me they
|
| Well, hypothalamus contains hundred of
| |
| | thought I was freshman (as I guess also
|
| centres that regulate your metabolism and
| |
| | 18 or 19). That time I was 33. Teenagers
|
| first of all, hormonal status. Studies of
| |
| | often start to talk to me in the way if I
|
| hypothalamus are complicated - mostly
| |
| | am another teenager. And so on.So, in
|
| there are postmortem studies of brain
| |
| | general it is really hard to measure
|
| sections. To perform functional study you
| |
| | rejuvenation. All measurements are mostly
|
| need to use micro-neurosurgical
| |
| | subjective. Even in well designed
|
| techniques (still very rude) and try to
| |
| | scientific trial you find either some
|
| register changes in a hundred or so cells
| |
| | description of biochemical changes (which
|
| out of several billions. Changes would
| |
| | doesn't say you anything about
|
| include minuscule production (nano and
| |
| | rejuvenation as it is) or some subjective
|
| Pico grams) of poorly defined
| |
| | descriptions - "patients felt much
|
| neurotransmitters. The infinitely small
| |
| | better, felt rejuvenated and invigorate".
|
| quantities of those neurotransmitters are
| |
| | How much rejuvenated? How many years were
|
| produced by only few out of hundreds cell
| |
| | reversed? It is very difficult to
|
| connections and exist only several
| |
| | estimate. If I say to a person that I
|
| nanoseconds. In general to study this
| |
| | have MD and PhD, he says "aha". Mentally
|
| area is more difficult than to look for a
| |
| | they immediately adjust and now they say
|
| needle in a haystack. If you consider
| |
| | that I am probably 30. OK. Sometime they
|
| that there are only few centres have
| |
| | just say: you look so young.Again 35 is
|
| appropriate expertise, you would
| |
| | not the age where you really can brag
|
| understand why the progress is relatively
| |
| | that the methods worked. I would wait
|
| slow. Even fewer labs study rejuvenation.
| |
| | couple more decades to say that there was
|
| Though there were reports that
| |
| | measurable effect. Unfortunately. You do
|
| transplantation of hypothalamic tissue
| |
| | not have the right for a mistake. If a
|
| from younger animals to older could
| |
| | method did not work , you can not go back
|
| result in rejuvenation-like effect.I
| |
| | and change it. You already are behind for
|
| mention this level because A)
| |
| | several years.But my personal, subjective
|
| hypothalamus regulates production of
| |
| | feeling is that the methods do work. I
|
| bunch of intermediate messengers that in
| |
| | believe that it is possible by tight
|
| turn activate hypophysis, that activate
| |
| | control maintain the level of younger
|
| adrenal glands, ovaries, thyroid gland
| |
| | organism. It just requires a lot of
|
| etc (maybe many other areas in th body)
| |
| | work.Below there is animation that might
|
| that in turn produce the hormones
| |
| | help to tune in the desired "optimal
|
| discussed above. (Full description you
| |
| | rejuvenation condition". Animation
|
| could find in a textbook of
| |
| | requires Flash file player I use that
|
| Endocrinology) B) because of complexity
| |
| | animation for myself. I doubt that it
|
| of hypothalamus it is a good candidate
| |
| | will necessarily help you. Maybe 1 out of
|
| were a "supreme cogwheel" of biological
| |
| | 10. If you are not sure, don't' touch it.
|
| clock may reside. One hint would be
| |
| | The animation contains some simple NLP
|
| proximity of epiphysis - small pea-like
| |
| | information.AnimationBasically looking at
|
| gland that produce melatonin and
| |
| | the animation couple times a week for 5
|
| regulates circadian rhythms. It would not
| |
| | min should start the tuning process (at
|
| be surprise that all that is
| |
| | least I feel so). You should target at
|
| interconnected in the hypothalamus. One
| |
| | the condition when you feel inexhaustible
|
| of objection - what is about worms? They
| |
| | energy, euphoria, normalized sleep, and
|
| do not have hypothalamus as it is. But
| |
| | some feelings that is hard to describe -
|
| they age and die as well as humans.
| |
| | like a fine tingling in your fingertips,
|
| Explanation would be that worms also have
| |
| | subjectively it feels like a pouring
|
| nervous system and some other part of it
| |
| | energy. It is difficult to explain, but
|
| may play the central role in the
| |
| | when you feel you understand it. If you
|
| biological clocks. Another explanation
| |
| | do not feel anything, it means it did not
|
| would be that there is no such centre at
| |
| | work, forget it.So to finish I would say
|
| all, everything happens on the lower
| |
| | that Rejuvenation is difficult but
|
| levels.I was interested in methods of
| |
| | probably possible to reach - at least in
|
| rejuvenation since childhood. Maybe I
| |
| | a certain degree. A.K.
|
