| Are You Half The Man Your Father Was?It
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| | peroxidase, glutathione reductase,
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| is a well-known fact that sperm counts
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| | superoxide dismutase.Some amount of all
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| have dropped by half in the last 50
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| | the antioxidant enzymes, which may
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| years, and that modern men have 20
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| | protect spermatozoa from oxidative
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| percent less semen volume than their
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| | attack, are also made by the epididymis
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| fathers (BMJ, 1992, volume 305).A recent
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| | during storage.The glutathione peroxidase
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| report from researchers in Aberdeen
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| | reductase enzymes play a central role in
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| presented preliminary data that suggests
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| | the defense against oxidative damage in
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| the sperm concentration of the men seen
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| | human sperm.Why is Glutathione important
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| in their clinic had declined by 29% over
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| | for Sperm Quality and Fertility?A
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| the past 14 years. (British Fertility
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| | decrease in levels of reduced glutathione
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| Society; 5 January 2004)Persistent
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| | (GSH) during sperm production is known to
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| organic pollutants (POPs) and
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| | disrupt the membrane integrity of
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| endocrine-disrupting chemicals from
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| | spermatozoa due to increased oxidative
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| normal, everyday plastics are known to
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| | stress.Intracellular glutathione levels
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| cause reproductive damage, as documented
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| | of spermatozoa are known to be decreased
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| in Theo Colborn's book "Our Stolen
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| | in certain populations of infertile men.
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| Future."Damage to sperm caused by
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| | Compared with a control group, the
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| exposure to common chemicals like
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| | infertile men in all groups had
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| alcohol, pesticides in food, has been
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| | significantly higher levels of ROS and
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| linked to lowered intelligence and
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| | lower levels of total antioxidants.There
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| behavioral disorders in
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| | is strong clinical evidence to show that
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| children.Lifestyle risk factors known to
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| | men diagnosed with infertility have high
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| decrease sperm quality include> Cigarette
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| | levels of oxidative stress that may
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| smoking> Alcohol consumption> Chronic
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| | impair the quality of their sperm.In some
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| stress> Nutritional deficiencies.Other
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| | groups, higher levels of ROS were
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| reasons for infertility include
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| | associated with lower sperm counts and
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| congenital factors, and health conditions
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| | defective sperm structure, while lower
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| like prostatitis and diabetes that can
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| | antioxidant levels correlated with
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| affect sperm production.Pollution is
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| | reduced sperm movement.Previous evidence
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| stealing our future, and there's little
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| | has also shown that oxidative stress can
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| anyone can do to avoid it. There may not
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| | decrease a sperm's life span, its
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| be a lot you can do to reduce your
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| | motility, and its ability to penetrate
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| exposure to persistent environmental
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| | the oocyst, or egg cell.Up to 40% of men
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| toxins.But there are definite measures
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| | with unexplained male infertility have
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| you can take to reduce the impact of the
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| | higher levels of free radical activity in
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| environmental pollutants and toxins on
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| | their bodies.Because men with high levels
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| your body.You can prevent and, to a
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| | of ROS have a seven-fold lower likelihood
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| certain extent, repair the damage they
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| | of inducing a pregnancy than men with
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| cause to your body, through a better
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| | lower levels, researchers recommend that
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| lifestyle and nutrition.Some nutritional
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| | treatment for infertile men should
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| therapies and antioxidants that have
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| | include strategies to reduce oxidative
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| proven beneficial in treating male
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| | stress and improve sperm quality.How can
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| infertility and improving sperm counts,
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| | Glutathione help in the Treatment of
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| sperm morphology and motility include:>
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| | Infertility?Glutathione is not only vital
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| Carnitine> Arginine> Zinc> Selenium>
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| | to sperm antioxidant defenses, but
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| Vitamin B-12> Vitamin C> Vitamin E>
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| | selenium and glutathione are essential to
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| Glutathione> Coenzyme Q10Studies show
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| | the formation of "phospholipid
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| that anti-oxidant supplementation -
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| | hydroperoxide glutathione peroxidase" -
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| glutathione in particular - can improve
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| | an enzyme present in spermatids - which
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| sperm quality, and possibly increase your
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| | becomes a structural protein in the
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| chances of conceiving.If you smoke,
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| | mid-piece of mature spermatozoa.When
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| drink, are exposed to stress, chemicals,
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| | either substance is deficient, it can
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| radiation, pesticides or take medication
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| | lead to instability of the mid-piece of
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| or drugs (like sulfasalazine,
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| | the spermatozoa, resulting in defective
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| ketoconazole, azulfidine, anabolic
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| | motility.Free radical scavengers - such
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| steroids, marijuana) that affect
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| | as glutathione - that restore the
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| fertility, you should consider taking an
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| | structure and function of
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| antioxidant supplement to reverse some of
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| | poly-unsaturated fatty acids (PUFA) in
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| the damage.Why are Antioxidants Important
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| | the cell membrane, can be used to treat
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| for Sperm Quality?Mammalian spermatozoa
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| | these cases.In a double-blind cross-over
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| are coated by a membrane rich in
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| | study of twenty infertile men, treatment
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| polyunsaturated fatty acids. These fatty
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| | with glutathione led to a statistically
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| acids are extremely susceptible to
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| | significant improvement of the sperm
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| oxidative damage by free radicals or
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| | quality.The study concerned men in whom
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| Reactive Oxygen Species (ROS) by a
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| | the sperm quality was poor due to
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| process called lipid peroxidation
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| | unilateral varicocele or germ-free
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| (LPO).Lipid peroxidation damages the
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| | genital tract inflammation - two
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| sperm cell membrane. It is considered to
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| | conditions in which ROS or other toxic
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| be the key mechanism of ROS-induced sperm
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| | compounds are indicated as causative
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| damage and leads to> Loss of sperm
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| | factors.Treatment with glutathione was
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| motility> Abnormal sperm morphology>
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| | also found to have a statistically
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| Reduced capacity for oocyte penetration>
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| | significantly positive effect on sperm
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| InfertilityTo protect sperm from damage,
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| | motility (in particular forward motility)
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| the body depends on powerful antioxidant
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| | and on sperm morphology.The findings of
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| enzymes in the body such as superoxide
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| | these studies indicate that glutathione
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| dismutase (SOD), catalase, and
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| | therapy could represent a possible
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| glutathione peroxidase/reductase (GPX
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| | therapeutical tool in cases where ROS or
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| GRD).Seminal plasma and spermatozoa have
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| | exposure to toxins is the probable cause
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| several antioxidant enzymes - glutathione
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| | of infertility.
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